Study shows taking Sustamine® L-Alanyl-L-Glutamine may reduce muscle protein breakdown after resistance exercise.

Sustamine® taken post exercise might reduce muscle protein breakdown

A University of Texas at Austin study showed taking Sustamine® L-Alanyl-L-Glutamine inhibits signaling proteins that activate protein degradation, which helps to maximize muscle protein build-up after resistance exercise.1

The study published April 3rd in the Journal Amino Acids, included 89 male Spraque-Dawley rats 2-3 months of age who performed resistance exercise. Immediately post exercise, the rats were given either whey protein (.4g/kg), low-dose Sustamine (.1g/kg), high-dose Sustamine (.5g/kg) or placebo, in random order. Sixteen rats were used as sedentary controls.

The primary findings were that “Sustamine® altered, immediately post exercise the phosphorylation state of signaling proteins in a manner that theoretically should reduce muscle protein breakdown, while whey protein accelerated the phosphorylation of proteins in the mTOR-dependent signaling pathway thereby theoretically activating muscle protein synthesis.”

Sustamine is a dipeptide of glutamine that provides several substantial benefits such as enhanced recovery, immune system support, and increased metabolic rate. This was one of the first studies to demonstrate its benefit on inhibiting muscle protein breakdown.


1) Wang, W, et al,. L-Alanylglutamine inhibits signaling proteins that activate protein degradation, but does not affect proteins that active protein synthesis after an acute resistance exercise. Amino Acids April 3, 2015; epub ahead of print. doi: 10.1007/s00726-015-1972-7

About Sustamine® L-Alanyl-L-Glutamine

Sustamine® L-Alanyl-L-Glutamine is a stable dipeptide of L-Alanine and L-Glutamine. Sustamine is more easily absorbed by the body than complex protein molecules. This makes Sustamine a highly effective ingredient for hydration, endurance and recovery.* Vegetarian, allergen-free and the only GRAS L-Alanyl-L-Glutamine, Sustamine is also tasteless, odorless, and stable in liquids.

Sustamine is an ingredient that works on multiple levels to help rehydrate the body and sustain energy levels during exertion. Sustamine combines L-Glutamine (the most important amino acid for stimulating muscle protein synthesis) and L-Alanine (an amino acid needed for rebuilding your body’s glycogen stores). Sustamine enhances performance and recovery in three primary ways. It helps:

  • Replace lost electrolytes and fluids
  • Repair damaged muscle proteins
  • Refill the body’s energy stores

For more information on Sustamine, visit:

**Sustamine® is a registered trademark of KYOWA HAKKO BIO CO. LTD.

About Kyowa Hakko USA

Kyowa Hakko USA is the North American sales office for KYOWA HAKKO BIO CO. LTD. (KYOWA HAKKO BIO), an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. KYOWA HAKKO BIO is the maker of branded ingredients including Cognizin® Citicoline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine® L-Alanyl-L-Glutamine.

« Back