Heart Health Study Shows CoQ10 Levels Maintained When Taking Pantesin® Pantethine

Pantesin® Pantethine Heart Health Supplement May Maintain CoQ10 Levels*  

The human body needs Coenzyme Q10 (CoQ10) to power cells and protect against free radicals. But people on some cholesterol-lowering drugs lose this critical substance due to the drugs’ adverse effects.

A study published in Vascular Health and Risk Management showed Pantesin® Pantethine – a Vitamin B5 derivative – not only helped lower LDL and non-HDL cholesterol levels, but also maintained CoQ10 levels.1 And unlike some cholesterol-lowering drugs, long-term use of Pantesin® does not lead to additional health risks.*

This is good news to people taking cholesterol-lowering drugs, as researchers believe “the combined use of [Pantesin®] pantethine and a low dose of [another cholesterol-lowering drug] may act synergistically to lower LDL-C while minimizing the adverse effects related to a high dose of [prescription drugs].”

“It’s in a person’s best interest to try alternatives to lower LDL and increase HDL cholesterol levels before opting for prescription therapy,” said Dr. John  Rumberger, one of the study scientists and recognized as the world's leading authority on cardiac and vascular imaging using EBT and CT Scanning. “A healthy diet and regimen of dietary supplements, such as pantethine, can have a beneficial effect without risking adverse side effects.”

Participants taking Pantesin® also saw an 11% decrease in LDL cholesterol levels compared to 3% of those taking placebo, according to the study. View the pantethine study »

Pantesin® can be found in CholestOff Complete®, a dietary supplement that combines esterified Reducol®, a proprietary blend of plant sterols and stanols (also called phytosterols) with Pantesin®. For more information, visit http://www.naturemade.com/supplements/cholestoff/cholestoff-complete.

About Pantesin® Pantethine

Pantesin® is a high-quality, pharmaceutical grade branded form of Pantethine, a derivative of vitamin B-5. Supplied worldwide by Daiichi Fine Chemical Co., Ltd, a subsidiary of Kyowa Hakko Bio Co. Ltd. (Kyowa Hakko Bio), and distributed by Kyowa Hakko U.S.A., the ingredient Pantesin can be found in many dietary supplements designed to support heart health. Pantesin has been well-researched for over 35 years, including human clinical studies in both Asian and North American countries, and has been shown to provide vital cardiovascular health benefits. For more information, visit www.pantesin.com.

About Kyowa Hakko USA

Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio, an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa Hakko Bio is the maker of branded ingredients including Cognizin® Citicoline, Pantesin® Pantethine, Setria® Glutathione, as well as Sustamine® L-Alanyl-L-Glutamine.


  1. Evans, M., Rumberger, J.A., Azumano, I., Napolitano, J., Citrolo. D., Kamiya, T. Pantethine, a derivative of vitamin B5, favorably alters total, LDL and non-HDL cholesterol in low to moderate cardiovascular risk subjects eligible for statin therapy: a triple-blinded placebo and diet-controlled investigation. Vascular Health and Risk Management 2014:10 89–100. 

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