Study Shows Citicoline Is Effective For Mild Vascular Cognitive Impairment

NEW YORK CITY (March 28, 2013) - Citicoline, a nutrient found in every cell of the human body, research has found that it may improve mild vascular cognitive impairment in elderly people who experience everyday lapses in memory.  Most recently, in an Italian study, it was found that this nutrient might also help prevent further decline in cognitive impairment.

The study, conducted by multiple health centers in Italy, included 349 patients with a mean age of 79.9. Participants who complained of memory lapses, but showed no signs of brain damage or Alzheimer's, were given 500mg of Citicoline (manufacturer: Kyowa Hakko Bio). Their memory was tested at three, six, and nine months, and then compared to tests given to a control group taking no supplements.

A "significant difference" was found between the study and control groups at both three and six months. Each group was given a series of questions called the Mini Mental State Examination (MMSE). Healthcare professionals use the MMSE common test to help diagnose and assess the progression and severity of memory problems. The control group MMSE scores declined significantly while the citicoline group remained at baseline. This significant difference is an indicator that citicoline has neuroprotective effects. Participants taking citicoline also reported no adverse side effects.

"In this study, citicoline was effective and well tolerated in patients with mild vascular cognitive impairment," the study stated. "Citicoline activates biosynthesis of phospholipids in neuronal membranes, increases brain metabolism as well as norepinephrine and dopamine levels in the central nervous system, and has neuroprotective effects during hypoxia and ischemia."

"Therefore, citicoline may be recommended for patients with mild vascular cognitive impairment," the study concluded.

The study abstract can be found at

For a full copy of the study, please send an email to

Other clinical trials have shown Cognizin Citicoline helps maintain normal cognitive function with aging, protects the brain from free radical damage, and is effective in combating certain neurodegenerative processes. For more information about Cognizin Citicoline, visit

About Cognizin
Cognizin is a branded form of Citicoline, a substance found in every cell of the body and especially vital to brain health.* Citicoline is broken down during intestinal absorption and, after passing through the blood/brain barrier, is reconstituted in the brain as citicoline.* Citicoline is a water-soluble compound that supplies precursors for the synthesis of phospholipids, including phosphatidyl-choline, a major constituent of brain tissue*; helps maintain normal levels of acetylcholine, a chemical that regulates memory and cognitive function*; enhances communication between neurons*; supports visual function*; protects neural structures from free radical damage*; enhances metabolism and healthy brain activity*; and helps sustain healthy cellular mitochondria for sustained energy*. Cognizin is also highly stable, GRAS, ultra-pure and allergen-free. For more information on Cognizin, visit

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

About Kyowa Hakko USA
Kyowa Hakko USA is the North American sales office for Kyowa Hakko Bio Co. Ltd., an international health ingredients manufacturer and world leader in the development, manufacturing and marketing of pharmaceuticals, nutraceuticals and food products. Kyowa is the maker of branded ingredients including Cognizin® Citicoline, Lumistor® L-Hydroxyproline, Pantesin® Pantethine, Setria® Glutathione, as well as SustamineTM L-Alanyl-L-Glutamine. For more information visit

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