NEW YORK, New York - Kyowa Hakko U.S.A., Inc. is offering an eight-page report on an in-depth study of the long-term toxicity of Natural Coenzyme Q10 (derived from fermentation). The information was published in August, 1999 in the Journal of Agriculture and Food Chemistry.
Prompted by the growing application of CoQ10 as a dietary supplement, the objective of the subject research was to rigorously test the chronic toxicity in an experimental design following principles for the safety assessment of food additives (FDA, 1982). Over a 52-week period, CoQ10 was administered daily as a solution to groups of laboratory rats. Each group received a specified dose, ranging from low to high dose levels.
Results of the research are presented for various criteria, among them ophthalmology, clinical and anatomical pathology, and toxicokinetic analyses. Further, the results indicated no adverse reaction at any of the CoQ10 dose levels studied.
Kyowa Hakko U.S.A. is among the world's leading producers and marketers of Coenzyme Q10, amino acids, nucleic acids, and bio-products for the pharmaceutical, nutritional supplement, and food processing industries.